I would play multiplier verses humans if there's a ranking system in place. I'm not one for just sitting in a lobby and eventually someone joins only to get smashed in 30 secs by someone with more spare time than me. sup com fa did this ranking system well. I also liked the 4 vs 4 because again there was labeled games novice intermediate expert etc and you had 3 others to back you up.
Otherwise i I just play me verses ai hard / very hard when I bet that I play me verses 2 when I beat that it's me verses 3 and so on so on. If the mates are free then and have the time for a full game then it's coop verses ai. Me and the mates just don't do verses each other matches ..mates want to do coop or team stuff Not kill each other.
if we are talking modes, I still think specific premade scenarios against the ai would be cool. especially if they where deliberately made to be as hard as possible and not easy to complete like single player always is. Scenarios so hard they come with a disclaimer if you loose forever, talk to the hand because the face ain't listening .. The krogoth encounter on the ta expansion pack springs to mind. I remember us all coming to school and all talking about whether we have completed the krogoth encounter yet ... One single mission verses the ai became the only thing played by many for weeks..