A necromancer raises the thread!
I have the exact same issue, no matter if i have any fences or if i remove them all, i can even hear the drive grinding away every time i move my mouse on the desktop, after disabling/uninstall the issue is gone.
This was not present on the old free version of fences, although that has other issues on windows 10.
I was using the old free version for quite a while on win 7 with no issues, after upgrade to win 10 the old fences would not allow me to move icons on desktop when installed so i thought id give the latest version a go and after the trial finally purchase it. But after using fences a bit i notice the grinding sound from my drive every time i moved the mouse cursor on the desktop, double click hiding/unhiding the fences would make the grinding go away for a few seconds and then it would be back. I had the latest fences 2.13 trial installed.
I should note that i probably wouldn't even have heard the grinding if i didn't have my computer on my desk (it has this nice shelf for the computer)
As much as i love fences and have gotten pretty used to them i have decided i rather not have this strain on my drive every time i move my mouse on the desktop. (oddly enough i spend quite a bit of time on my desktop, its why the fences were so useful) 
If there is anything specific i can provide to help you find the cause, i will gladly help.
