Well personally I used Norton for a long time but got tired of it's issues, so I went to mcafee, and it had even more issues in my opinion, but then my good friend introduced me to AVAST. And I have never even thought of switching. In my opinion it out performs most other AVs and it is free unless you are a business.
I also currently use Windows Defender and Ad-Aware SE.
I haven't had any issues in a while with this set-up.