Well, if you upped the system requirements a bit (very easily done as the game would not be released for quite some time and if you follow Moore's law, computers should be vastly improved by that time), you could justify having larger amounts of guns among other things so that you might not have caps getting slaughtered by critical mass SC left and right.
Surely the Kol, Egg, and Mothership would come back, but I don't know about the others. The Vasari caps would likeyl be the most unchanged. Perhaps a new one or two while the TEC would likely have brand new ones that are more powerful. The Advent would likely have even better synergies than currently. Idk, my two cents...